Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.

Proc Natl Acad Sci U S A
Authors
Keywords
Abstract

In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense of less fit mutant alleles carrying the CQ resistance (CQR) marker K76T. In low-transmission settings, such as South America, drug resistance mutations can attain 100% prevalence, thereby precluding the return of WT parasites after the complete removal of drug pressure. In French Guiana, despite the fixation of the K76T allele, the prevalence of CQR isolates progressively dropped from >90% to

Year of Publication
2015
Journal
Proc Natl Acad Sci U S A
Volume
112
Issue
37
Pages
11672-7
Date Published
2015 Sep 15
ISSN
1091-6490
URL
DOI
10.1073/pnas.1507142112
PubMed ID
26261345
PubMed Central ID
PMC4577156
Links
Grant list
HHSN272200900018C / AI / NIAID NIH HHS / United States
R01 AI050234 / AI / NIAID NIH HHS / United States
F30 AI114070 / AI / NIAID NIH HHS / United States
T32 GM007367 / GM / NIGMS NIH HHS / United States
R01 AI109023 / AI / NIAID NIH HHS / United States
HHSN272200900018C / PHS HHS / United States
R01AI50234 / AI / NIAID NIH HHS / United States
R01AI109023 / AI / NIAID NIH HHS / United States