Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Bioorg Med Chem Lett
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Abstract | A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations. |
Year of Publication | 2013
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Journal | Bioorg Med Chem Lett
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Volume | 23
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Issue | 6
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Pages | 1834-8
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Date Published | 2013 Mar 15
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ISSN | 1464-3405
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URL | |
DOI | 10.1016/j.bmcl.2013.01.025
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PubMed ID | 23403082
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Grant list | 1 U54 HG005032-1 / HG / NHGRI NIH HHS / United States
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